Rajashekhar Kanchanapally

Rajashekhar Kanchanapally

College Of Arts And Sciences

Department of Natural Sciences


Assistant Professor


210-784-2699
Rajashekhar.Kanchanapally@tamusa.edu
View CV

Biography

Rajashekhar Kanchanapally earned his Ph.D. in Chemistry from Jackson State University and completed postdoctoral training at the Mitchell Cancer Institute at the University of South Alabama and at the University of Memphis. Before joining A&M–San Antonio, he held faculty positions at Mississippi Valley State University and Tougaloo College, where he taught a variety of courses including General Chemistry, Organic Chemistry, Chemical Instrumentation, and Biochemistry. He also has industry experience as a Quality Analyst at Dr. Reddy’s Laboratories in Hyderabad, India, where he gained extensive experience in analytical testing and quality control of pharmaceutical products.

Dr. Kanchanapally’s research focuses on the development of nanomaterial- and exosome-based platforms for targeted drug delivery, cancer therapeutics, and biosensing applications. His work aims to improve the efficiency of therapeutic agents, reduce toxicity, and advance approaches for early detection and treatment of cancer. He has published numerous peer-reviewed articles, book chapters, and conference papers, and his research has been widely cited in the scientific community.

He is deeply committed to mentoring students and regularly involves undergraduate and high school researchers in his laboratory projects. Many of his students have presented at professional scientific conferences and pursued graduate studies and careers in STEM fields.

Publications

  1. Cancer Cell-Derived Exosomes as the Delivery Vehicle of Paclitaxel to Inhibit Cancer Cell Growth. Kanchanapally, R.*; and K. Brown. J Cancer Discovery 2022, 1, 49.
  2. Exosomal Formulation Escalates Cellular Uptake of Honokiol Leading to the Enhancement of Its Antitumor Efficacy. Kanchanapally, R.; Khan, M. A.; Deshmukh, S. K.; Srivastava, S.K.; Khushman, M.; Singh, S.; Ajay Pratap Singh. ACS Omega 2020, 5, 23299.
  3. Epigallocatechin Gallate-Gold Nanoparticles Exhibit Superior Antitumor Activity Compared to Conventional Gold Nanoparticles: Potential Synergistic Interactions. Chavva, S.R.; Deshmukh, S.K.; Kanchanapally, R.; Tyagi, N.; Coym, J.W.; Singh, A.P.; Singh, S. Nanomaterials 2019, 9 (3), 396.
  4. Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis. Kanchanapally, R.; Deshmukh, S. K.; Chavva, S. R.; Tyagi, N.; Srivastava, S. K.; Patel, G. K.; Singh, A. P.; Singh, S. Int J Nanomedicine 2019, 14, 531-541.
  5. Multifunctional Three-Dimensional Chitosan/Gold Nanoparticle/Graphene Oxide Architecture for Separation, Label-Free SERS Identification of Pharmaceutical Contaminants, and Effective Killing of Superbugs Jones, S.; Pramanik, A.; Kanchanapally, R.; Viraka Nellore, B. P.; Begum S.; Sweet, C.; and Ray, P. C. ACS Sustainable Chem. Eng., 2017, 5 (8), 7175–7187
  6. Hybrid Theranostic Platform for Second Near-IR Window Light Triggered Selective Two-Photon Imaging and Photothermal Killing of Targeted Melanoma Cells Tchounwou, C.; Sinha, S. S.; Viraka Nellore, B. P.; Pramanik, A.; Kanchanapally, R.; Jones, S.; Chavva, S. R.; Ray, P. C. ACS Appl. Mater. Interfaces 2015, 7 (37), 20649–20656. 
  7. Bio-Conjugated CNT-Bridged 3D Porous Graphene Oxide Membrane for Highly Efficient Disinfection of Pathogenic Bacteria and Removal of Toxic Metals from Water Viraka Nellore, B. P.; Kanchanapally, R.; Pedraza, F.; Sinha, S. S.; Pramanik, A.; Hamme, A. T.; Arslan, Z.; Sardar, D.; Ray, P. C. ACS Appl. Mater. Interfaces 2015, 7 (34), 19210–19218. 
  8. Hybrid Graphene Oxide Based Plasmonic-Magnetic Multifunctional Nanoplatform for Selective Separation and Label-Free Identification of Alzheimer’s Disease Biomarkers  Demeritte, T.; Viraka Nellore, BP.; Kanchanapally, R.; Sinha, S. S.; Pramanik, A.; Chavva, S. R.; Ray P. C. ACS Appl. Mater. Interfaces, 2015, 7(24), 13693-13700. 
  9. Antimicrobial Peptide-Conjugated Graphene Oxide Membrane for Efficient Removal and Effective Killing of Multiple Drug Resistant Bacteria Kanchanapally, R.; Viraka Nellore, BP.; Sinha, S.S.; Pedraza, F.; Jones, S.; Pramanik, A.; Chavva, S. R.; Tchounwou, C.; Shi, Y.; Vangara, A.; Sardar, D.; Ray. P. C. RSC Adv. 2015, 5, 18881-18887. 
  10. Long Range Two-Photon Scattering Spectroscopy Ruler For Screening Prostate Cancer Cells Sinha, S.S.; Paul, D.; Kanchanapally, R.; Pramanik, A.; Chavva, S. R.; Viraka Nellore, BP.; Jones, S.; Ray. P. C. Chem. Sci., 2015, 6, 2411-2418. 
  11. Aptamer-Conjugated Graphene Oxide Membranes for Highly Efficient Capture and Accurate Identification of Multiple Types of Circulating Tumor Cells Viraka Nellore, BP; Kanchanapally, R.; Pramanik, A.; Sinha, S. S.; Chavva, S. R.; Hamme, II, A.; Ray P. C. Bioconjugate Chem., 2015, 26(2), 235-242. 
  12. Accurate Identification and Selective Removal of Rotavirus Using a Plasmonic–Magnetic 3D Graphene Oxide Architecture. Fan, Z.; Yust, B.; Viraka Nellore, BP; Sinha, S. S.; Kanchanapally, R.; Crouch, R. A.; Pramanik, A.; Chavva, S. R.; Sardar, D.; Ray, P. C. J. Phys. Chem. Lett. 2014, 5, 3216–3221. 
  13. Theranostic Graphene Oxide for Prostate Cancer Detection and Treatment. Chavva, S. R.; Pramanik, A.; Nellore, B. P. V.; Sinha, S. S.; Yust, B.; Kanchanapally, R.; Fan, Z.; Crouch, R. A.; Singh, A. K.; Neyland, B.; Ray, P.C. Part. Part. Syst. Charact. 2014, 31, 1252-1259. 
  14. Graphene Oxide–Gold Nanocage Hybrid Platform for Trace Level Identification of Nitro Explosives Using a Raman Fingerprint. Kanchanapally, R.; Sinha, S. S.; Fan, Z.; Dubey, M.; Zakar, E.; Ray, P. C. J. Phys. Chem. C 2014, 118, 7070–7075.
  15. Aptamer-Conjugated Theranostic Hybrid Graphene Oxide with Highly Selective Biosensing and Combined Therapy Capability. Viraka Nellore, B. P.; Pramanik, A.; Chavva, S. R.; Sinha, S. S.; Robinson, C.; Fan, Z.; Kanchanapally, R.; Grennell, J.; Weaver, I.; Hamme, A. T.; Ray, P.C. Faraday Discuss 2014, 175, 257-271.
  16. Multifunctional Hybrid Graphene Oxide for Label-Free Detection of Malignant Melanoma from Infected Blood. Kanchanapally, R.; Fan, Z.; Singh, A. K.; Sinha, S. S.; Ray, P. C. J. Mater. Chem. B 2014, 2, 1934–1937.
  17. Hybrid Graphene Oxide Based Ultrasensitive SERS Probe for Label-Free Biosensing. Fan, Z.; Kanchanapally, R.; Ray, P. C. J. Phys. Chem. Lett. 2013, 4, 3813–3818. 
  18. Development of a Long-Range Surface-Enhanced Raman Spectroscopy Ruler. Singh, A. K.; Khan, S. A.; Fan, Z.; Demeritte, T.; Senapati, D.; Kanchanapally, R.; Ray, P. C. J. Am. Chem. Soc. 2012, 134, 8662–8669. 
  19. A Gold nanocage–CNT Hybrid for Targeted Imaging and Photothermal Destruction of Cancer Cells. Khan, S. A.; Kanchanapally, R.; Fan, Z.; Beqa, L.; Singh, A. K.; Senapati, D.; Ray, P. C. Chem. Commun. 2012, 48, 6711–6713. 
  20. Length Dependent NLO Properties of 2D Hollow Gold Nanoprisms Formed by Guided Assembly. Senapati, D.; Senapati, T.; Wate, P. S.; Kanchanapally, R.; Fan, Z.; Singh, A. K.; Ray, P. C. Chem. Commun. 2012, 48, 6034–6036. 
  21. Synthesis of Highly Fluorescent Water-Soluble Silver Nanoparticles for Selective Detection of Pb(II) at the Parts per Quadrillion (PPQ) Level. Singh, A. K.; Kanchanapally, R.; Fan, Z.; Senapati, D.; Ray, P. C. Chem. Commun. 2012, 48, 9047–9049. 
  22. Highly Efficient SERS Substrate for Direct Detection of Explosive TNT Using Popcorn-Shaped Gold Nanoparticle-Functionalized SWCNT Hybrid. Demeritte, T.; Kanchanapally, R.; Fan, Z.; Singh, A. K.; Senapati, D.; Dubey, M.; Zakar, E.; Ray, P. C. Analyst 2012, 137, 5041–5045 .
  23. Highly Selective SERS Probe for Hg(II) Detection Using Tryptophan-Protected Popcorn Shaped Gold Nanoparticles. Senapati, T.; Senapati, D.; Singh, A. K.; Fan, Z.; Kanchanapally, R.; Ray, P. C. Chem. Commun. 2011, 47, 10326–10328.

Book Chapters:

  1. “The Potential of Antimicrobial Peptides in Breast Cancer Treatment”. Viraka Nellore, BP.; Kanchanapally, R. Antimicrobial Peptides: Functions, Mechanisms of Action and Role in Health and Disease. Nova Science Publishers, NY.
  2. “Antimicrobial Peptide-Modified Nanomaterials for Detection and Extermination of Bacteria”. Kanchanapally, R.; Shodubi, O. P.; Okanlawon, M. R.; Viraka Nellore, B. P. Antimicrobial Peptides: Functions, Mechanisms of Action and Role in Health and Disease. Nova Science Publishers, NY.
  3. "Two-Dimensional Graphene Material for Food Pathogen Diagnosis”. Viraka Nellore, BP.; Kanchanapally, R.; Demeritte, T.; Ray, P. C. Food Poisoning: Outbreaks, Bacterial Sources and Adverse Health Effects. Nova Science Publishers, NY.
  4. "Detection of Melamine from Food in Parts per Quadrillion Level Using Functionalized Graphene Oxide-Gold Nanoparticle Hybrid SERS Platform". Kanchanapally, R.; Fan, Z.; Wesley, W.; Viraka Nellore, BP.; Crouch, R. A.; Sinha, S. S.; Pramanik, A.; Chavva S. S.; Ray, P.C. Food Poisoning: Outbreaks, Bacterial Sources and Adverse Health Effects. Nova Science Publishers, NY.
  5. “Bioconjugated Gold Nanoparticle for Rapid Capture and Targeted Photothermal Lysis of Pathogenic Bacteria”. Ray, P.C.; Khan, S. A.; Singh A. K.; Senapati D.; Fan, Z.; Demeritte, T.; Kanchanapally, R.; In Nanomaterials for Biomedicine; ACS Symposium Series; American Chemical Society.

 

Course Teachings

SubjectNumberSectionDescriptionTermSyllabi
CHEM 3131 01L Quantitative Analysis Lab Fall 2025 Syllabus
CHEM 1112 03L General Chemistry Lab II Fall 2025 Syllabus
CHEM 3331 001 Quantitative Analysis Fall 2025 Syllabus